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<span style="font-size: 11.5pt; ">Dear Colleague, </span><span style="font-family: Tahoma, sans-serif; "></span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-size: 11.5pt; "> </span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-size: 11.5pt; ">The <i>Allen Institute for Brain Science</i> is embarking on a multiyear project to study neural computation and coding in the mouse cortex. An integral part of this effort is the <i>Modeling, Analysis, and Theory Group</i> at
the Institute, which presently has four openings for scientist positions focusing in the following areas of computational neuroscience:</span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-family: Symbol; ">·</span><span style="font-size: 7pt; "> </span><span style="font-size: 11.5pt; ">Biophysical modeling of information processing in the cortex,</span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-family: Symbol; ">·</span><span style="font-size: 7pt; "> </span><span style="font-size: 11.5pt; ">Detailed single-neuron and network modeling of the mouse visual cortex V1,</span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-size: 11.5pt; "> </span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-family: Symbol; ">·</span><span style="font-size: 7pt; "> </span><span style="font-size: 11.5pt; ">Modeling of short term synaptic plasticity at the cell type and network level,</span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-size: 11.5pt; "> </span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-family: Symbol; ">·</span><span style="font-size: 7pt; "> </span><span style="font-size: 11.5pt; ">Developing visualization and analysis systems for large-scale imaging data.</span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-size: 11.5pt; ">The first two scientists will employ realistic neuronal cell morphology, biophysical mechanisms, and connectivity to construct computer simulations ranging from single neurons to many thousands of cells in the mouse visual
cortex, aiming to computationally recreate intracellular, transmembrane, and extracellular activity. The third position will primarily focus on constructing mathematical tools to parameterize synaptic plasticity models between specified cell types in the thalamo-cortical
circuits and extend existing models if they fail to accurately describe the observed data. The fourth scientist will work toward developing semi- and fully-automated image reconstruction of neuron morphology of light and electron microscopy, providing crucial
tools for the analysis of the massive amount of imaging data generated at the Allen Institute. An overarching theme for all four positions will be close interaction with experimental teams at the Allen Institute in designing optimal protocols, analyzing their
outcome, and deciphering functional implications of the mechanisms studied.</span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-size: 11.5pt; ">These positions are offered at the level of “Scientist I” and are typically filled by applicants within a few years of finishing their PhD thesis work. </span> <span style="font-size: 11.5pt; ">We strongly encourage qualified
individuals with PhD in relevant disciplines to apply. To learn more about individual positions and to submit applications, please visit our web site,</span><a href="http://www.alleninstitute.org/about_us/careers.html" target="_blank" style="color: blue; text-decoration: underline; "><span style="font-size: 11.5pt; color: purple; ">http://www.alleninstitute.org/about_us/careers.html</span></a><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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Please share this with colleagues in your department.<span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-size: 11.5pt; "> </span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-size: 11.5pt; ">Sincerely, </span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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<span style="font-size: 11.5pt; ">Mike Hawrylycz, Ph.D.<span style="color: rgb(31, 73, 125); ">, </span>Director of Modeling, Analysis and Theory </span><span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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Christof Koch, Ph. D., Chief Scientific Officer<span style="font-size: 10pt; font-family: Tahoma, sans-serif; "></span></p>
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