<div dir="ltr"><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:11pt">Dear all,</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:11pt"> </span></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif">a 2-year PostDoc position for developing computational models of disease progression in dementia patients is available within my lab.<b><br><br><strong>About the project</strong></b><br>The most ideal time to intervene with disease-modifying treatment is early on before significant neurodegenerative change and neuronal loss has occurred. However, another highly relevant consideration is improvements in subtype diagnosis i.e. determination of the type of neurodegenerative process giving rise to dementia. Differentiation is crucial as there are different management trajectories for each disease; for example, neuroleptic drugs which are given to AD can be fatal in the DLB group. Promising preliminary data, using simulation of disease progression, suggest that we may be able to make an early diagnosis even when subtle changes cannot be detected with the current machine learning approach. Going beyond machine learning subtype classification, our study aims to develop a simulation-based model of disease progression that can facilitate early treatment of the disease leading to improved outcomes for patients and reduced overall healthcare costs.<br><br><strong>Available RA position</strong><br>As part of this project, the lab of Prof. Marcus Kaiser (</span><span lang="EN-US"><a href="http://www.dynamic-connectome.org/" target="_blank" style="color:blue"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(140,104,203)"><span style="text-decoration-line:none">http://www.dynamic-connectome.org/</span></span></a></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif"> ), with joint supervision from the lab of Prof. John-Paul Taylor (</span><span style="font-size:11pt;font-family:Arial,sans-serif"><a href="https://www.lewybodylab.org/" target="_blank" style="color:blue"><span style="color:rgb(5,99,193)">https://www.lewybodylab.org/</span></a></span><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif"> ), are seeking a talented and enthusiastic research assistant with a PhD awarded, or a PhD thesis about to be submitted, in computational biology or related subjects; prior experience in the neurosciences is desirable.<br> <br>The aim of this joint project, between Newcastle University and Korea University, is to developing more accurate dementia progression models that can inform diagnosis and treatment of patients using neuroimaging (MRI and PET) data. Objectives of this position are, first, to observe brain network features of dementia patients and how these features are changing with disease progression. Second, to develop computational models of how structural and functional connectivity will change over time in these patients. Third, testing whether the models can reproduce the actual progression and to test different hypotheses about the underlying causes of brain network changes. <br><br>Good communication skills, very strong dynamics modelling skills, and a track record of previous peer-reviewed journal publications. You will have experience with neuroimaging and/or computer simulations. The position will include visits to our collaborators in South Korea (Profs Cheol Han and Hyun-Ghang Jeong, Korea University). <br><br><strong>Research Environment</strong><br>Neuroinformatics at Newcastle University in the UK covers a range of topics from electrophysiology to neuroimaging. We are among the pioneers in connectome analysis and the establishment computational models to inform interventions in patients, e.g. through the £10m Wellcome Trust/EPSRC-funded CANDO project. Our strength is a close collaboration between computational, experimental, and clinical researchers. We currently have a team of 13 faculty members in the areas of Neuroinformatics and Neurotechnology: </span><span lang="EN-US"><a href="http://neuroinformatics.ncl.ac.uk/" target="_blank" style="color:blue"><span style="font-size:11pt;font-family:Arial,sans-serif;color:rgb(140,104,203)"><span style="text-decoration-line:none">http://neuroinformatics.ncl.ac.uk/</span></span></a></span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US"><b>How to Apply</b><br></span><span lang="EN-US">Apply before 23 February 2020 at </span><a href="https://jobs.ncl.ac.uk/job/Newcastle-Research-Assistant-Associate-in-Computational-Modelling-Dementia-Progression/581938101/" target="_blank" style="color:blue">https://jobs.ncl.ac.uk/job/Newcastle-Research-Assistant-Associate-in-Computational-Modelling-Dementia-Progression/581938101/</a></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-size:12pt;font-family:Calibri,sans-serif"><span style="font-size:11pt;font-family:Arial,sans-serif">For informal queries, please contact Dr Marcus Kaiser, <a href="mailto:Marcus.Kaiser@ncl.ac.uk" target="_blank" style="color:blue">Marcus.Kaiser@ncl.ac.uk</a></span></p><p class="MsoNormal" style="margin:0cm 0cm 12pt;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-size:12pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:11pt;font-family:Arial,sans-serif"> </span><span lang="EN-US"></span></p><div><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><div dir="ltr"><p><br></p><div style="color:rgb(0,0,0);font-family:-webkit-standard"><div><div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt">Best,</span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt"> Marcus</span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt"> </span></p></div><div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif">--</span><span lang="EN-US" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt"> </span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif">Marcus Kaiser, Ph.D. FRSB <a href="https://twitter.com/ConnectomeLab" target="_blank" style="color:rgb(0,0,106)">@ConnectomeLab</a></span><span lang="EN-US" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif">Professor of Neuroinformatics</span><span lang="EN-US" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:10.5pt;font-family:Arial,sans-serif">Interdisciplinary Computing and Complex Biosystems (ICOS) Research Group</span><span lang="EN-US" style="font-size:10.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">School of Computing</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">Urban Sciences Building</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">Newcastle University</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">1 Science Square</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">Science Central</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">Newcastle upon Tyne</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt">NE4 5TG</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:13.5pt">UK</span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:13.5pt"> </span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="DE" style="font-size:13.5pt;font-family:Arial,sans-serif">Lab website:</span><span lang="DE" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif"><a href="http://www.dynamic-connectome.org/" target="_blank" style="color:rgb(0,0,106)"><span lang="DE">http://www.dynamic-connectome.org</span></a></span><span lang="DE" style="font-size:13.5pt;font-family:Arial,sans-serif">/ </span><span lang="DE" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="DE" style="font-size:13.5pt"> </span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="DE" style="font-size:13.5pt;font-family:Arial,sans-serif">Neuroinformatics@Newcastle:</span><span lang="DE" style="font-size:13.5pt"></span></p></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif"><a href="http://neuroinformatics.ncl.ac.uk/" target="_blank" style="color:rgb(0,0,106)"><span lang="DE">http://neuroinformatics.ncl.ac.uk</span></a></span><span lang="DE" style="font-size:13.5pt;font-family:Arial,sans-serif">/ </span><span lang="DE" style="font-size:10.5pt;font-family:Arial,sans-serif"> </span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="DE" style="font-size:10.5pt;font-family:Arial,sans-serif"> </span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:13.5pt;font-family:Arial,sans-serif">Neuroinformatics UK:</span></p><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif"><a href="http://www.neuroinformatics.org.uk/" target="_blank" style="color:rgb(0,0,106)"><span lang="EN-GB">http://www.neuroinformatics.org.uk/</span></a></span><span style="font-size:13.5pt"></span></p></div></div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span style="font-size:10.5pt"> </span></p></div><div><div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif"><span lang="EN-US" style="font-size:13.5pt;font-family:Arial,sans-serif">Neuroinformatics one-year master programme:</span><span lang="EN-US" style="font-size:13.5pt"></span></p></div></div></div></div></div><p class="MsoNormal" style="margin:0cm 0cm 0.0001pt;font-size:11pt;font-family:Calibri,sans-serif;color:rgb(0,0,0)"><span lang="EN-US" style="font-size:13.5pt"><a href="http://research.ncl.ac.uk/neuroinformatics/study" target="_blank" style="color:rgb(0,0,106)">http://research.ncl.ac.uk/neuroinformatics/study</a></span></p></div></div></div></div></div></div></div></div></div></div><br clear="all"><div><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div><div dir="ltr"><div dir="ltr"><div dir="ltr"><div 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